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International Society of Cardiovascular Pharmacotherapy Latest News

Posted on October 13, 2026

Stress management in the OR takes practice, but is trainable

NEW ORLEANS — In the high-stakes environment of ocular surgery, stress management is a trainable skill that can be improved with strategic planning and practice, according to a speaker. At the American Academy of Ophthalmology meeting, Erin S. Seefeldt, MD, an ophthalmologist and founder of Physician Performance Lab, highlighted the scope of burnout among physicians. A survey of 592 participants found that 37% of U.S. ophthalmologists reported burnout symptoms, which can serve as a career-ending factor for a number of clinicians. However, Seefeldt said that combatting it is practical. “This

Posted on October 13, 2026

Cardioprotection limited in adult hematologic malignancies

Most adults with hematologic cancers, such as acute myeloid leukemia and diffuse large B-cell lymphoma, do not receive cardioprotective prophylaxis with first-line anthracycline therapy. An evaluation of more than 13,000 patients showed less than 3% with de novo AML and less than 2% with DLBCL received frontline cardioprotection with dexrazoxane or liposomal anthracycline formulations. “We had certainly hypothesized that the uptake would be low, but I don’t think we had suspected that it would be as low as it was,” Alexis C. Boulter, MD, MS, attending physician at Children’s Hospital of

Posted on October 13, 2026

Baroreflex activation therapy may benefit off-label HF population

PHOENIX — Baroreflex activation therapy is commonly used off-label in a registry of real-world patients with heart failure who were well treated with guideline-directed medical therapy, a speaker reported. Baroreflex activation therapy (Barostim, CVRx) was associated with stable hemodynamics, improved NYHA functional class and left ventricular ejection fraction and promising survival rates out to 3 years in both the overall cohort and in a subgroup who had baseline characteristics consistent with the current FDA indication, according to data from the REBALANCE study presented at the Heart

Posted on October 12, 2026

Lung recipients have highest cancer rates among organ transplants

Cancer incidence after solid organ transplant varies significantly based on transplant and malignancy type. A study of more than 620,000 patients who received heart, kidney, liver or lung transplant showed that patients who had lung transplants had the greatest incidence rates for solid tumors, nonmelanoma skin cancer and posttransplant lymphoproliferative disorder (PTLD). Additionally, bladder, colorectal, genital and lung cancer incidence increased over time, whereas melanoma, thyroid cancer and PTLD rates dropped after high early incidence. “This is something we should be more observant of,

Posted on October 12, 2026

Data on PDE9 inhibition in HF mixed; more research planned

PHOENIX — Tovinontrine increased plasma cyclic guanosine monophosphate levels in patients with HF with reduced or preserved ejection fraction but did not change N-terminal pro-B-type natriuretic peptide levels, a speaker reported. A post hoc analysis of data indicated a possible inverse dose response relationship with lower-dose tovinontrine (Cardurion Pharmaceuticals) causing less plasma cyclic guanosine monophosphate elevation and greater reduction in NT-proBNP, according to research presented at the Heart Failure Society of America Annual Scientific Meeting. James E. Udelson, MD, chief of

Posted on October 9, 2026

Diet, cardiovascular health, social factors impact glaucoma risk

NEW ORLEANS — Although polygenic risk scores can be a useful tool in glaucoma, ophthalmologists should also be aware of patient lifestyle and environmental factors, according to a presenter. “We all routinely encounter patients in our clinics who have a relative who has lost their vision from glaucoma. They always ask us, ‘Is there anything I can do to lower my risk?’” Inas F. Aboobakar, MD, said during a presentation at Glaucoma Subspecialty Day at the American Academy of Ophthalmology meeting. “We know in recent years from many studies that glaucoma is a

Posted on October 9, 2026

What is ‘healthy light’? Permanent transition to LED bulbs may cause potential harms

By 2027, LED lighting will be the predominant source of artificial light available worldwide, after a permanent transition that some physicians are concerned will cause unique, modern-day health risks. LED, or light-emitting diode, is a type of light that harnesses blue light wavelengths to create visible white light. In November 2023, delegates from 147 countries agreed under the United Nations’ Minamata Convention on Mercury treaty to phase out fluorescent lighting by 2027 due to environmental reasons, including mercury exposure, extreme energy waste and high greenhouse gas emissions.

Posted on October 9, 2026

CGM may help predict future CVD risk for adults without diabetes

Continuous glucose monitoring may be used to predict cardiovascular disease risk among adults without prevalent type 2 diabetes or CVD, according to findings published in Diabetes Care. In an analysis of CGM data from 1,356 people without diabetes who participated in the Framingham Heart Study, researchers examined associations between both glycemic measures and CGM profiles and 10-year CVD risk. Bahar Bakhshi, MS, a PhD candidate in molecular and translational medicine at Boston University School of Medicine, said the study showed how glycemic patterns found in CGM data could provide

Posted on October 9, 2026

No survival benefit from community first responder activation

MUNICH — Community first responder activation did not improve 30-day survival in patients with out-of-hospital cardiac arrest, according to the HeartRunner trial presented at the European Society of Cardiology Congress. “To try to improve survival, community first responder programs are now being implemented worldwide at a rapid pace, meaning that the dispatch center can actually alert community responders, normal citizens close to the cardiac arrest victim, to go start CPR and hopefully bring an [automated external defibrillator] and perform early defibrillation to improve

Posted on October 9, 2026

‘We need healthcare voices’ for health education on TV, online

NEW YORK — Now more than ever, perspectives from people working in healthcare are needed outside of the clinic, according to a speaker at the 2026 Women in Nephrology Leadership Conference. “We need healthcare voices,” Tara Narula, MD, professor of cardiology at Zucker School of Medicine at Hofstra/Northwell, said during a fireside chat. “We need people who have the training and the background to communicate the science appropriately.” Narula is also chief medical correspondent for ABC News and a physician author. She touts the mediums of television and other media platforms for their potential

Posted on October 9, 2026

Once-daily inhaled mosliciguat yields improvements in PH-ILD

Adults with pulmonary hypertension associated with interstitial lung disease receiving once-daily inhaled mosliciguat had a larger decrease in pulmonary vascular resistance at week 16 vs. placebo, according to phase 2 trial topline data. These findings on mosliciguat (Roivant, Pulmovant), a potential first-in-class sGC activator, were simultaneously presented at the European Respiratory Society International Congress. “Mosliciguat demonstrated improvements across multiple clinically relevant domains, including hemodynamics, exercise capacity and biomarkers of right ventricular strain,” Parth M.

Posted on October 8, 2026

Finding meaning in tragedy: What clinicians can learn from Pike’s execution attempt

Christa Pike was sentenced to death for murder in 1996. On Sept. 30, she was injected with two doses of pentobarbital but survived. During the execution attempt, witnesses reported that Pike said she was in pain and then appeared to be snoring before she was transported to a hospital. Pike’s attorneys said she gained consciousness and the ability to speak on Oct. 6, although she is unable to eat, swallow or move her swollen hands and arms, and has pneumonia and “cognitive confusion,” according to reporting from Reuters. Lewis Nelson, MD, MBA, dean and chief of health affairs at Florida Atlantic

Posted on October 8, 2026

Kidney disease often overlooked in women

Kidney disease in women may be often underdiagnosed and undertreated due to lack of sex-specific research and recognition of reproductive health as an important variable, according to a scientific statement published in Circulation. The American Heart Association issued a scientific statement calling on greater recognition and treatment of kidney disease in women; assessment of reproductive health during kidney care; and increased enrollment of women in clinical trials to improve knowledge of sex-specific treatment outcomes. The authors reported that approximately one in 10 women globally have

Posted on October 8, 2026

Q&A: ACP updates guidance on ethical AI use

In a new position paper, ACP detailed key principles for ethical, responsible AI use in healthcare. AI — when implemented thoughtfully — has the potential to strengthen clinical decision-making, advance patient care “and preserve the central role of the patient-physician relationship,” according to an ACP press release. However, the technology is being adopted rapidly and “there has not been consensus on guidance around issues” like disclosure, fairness and privacy, and both “physicians and patients need practical ethical guidance to help ensure these technologies are used responsibly,

Posted on October 7, 2026

US heart death declines slow, but decades of disparities remain

Cardiovascular disease deaths in the U.S. continued to decline, but progress has slowed and disparities in CVD-related mortality persist, according to research published in the Journal of the American College of Cardiology. Total CVD mortality from 2000 to 2019 remained highest among the Black population in the U.S., followed by Indigenous, white, Hispanic and Asian individuals, researchers reported. “For clinical practice, these findings point to the value of integrating local epidemiology into risk assessment, outreach and care delivery,” George A. Mensah, MD, FACC, director of the Center for

Posted on October 7, 2026

Governance key to balancing AI augmentation, risk for deskilling

An aircraft’s autopilot can guide every aspect of a flight, from takeoff to landing. But it is expected, and reassuring to know, that a pilot has the skills to intervene and assume manual control at any time, especially during an emergency. There is a similar expectation for healthcare professionals, who increasingly encounter AI’s expansion in practice to aid clinical diagnoses, documentation and decision-making. The concern? That overreliance on AI could eventually erode clinical skills and competencies, a phenomenon dubbed “deskilling.” “Research is showing that there is a fine line between

Posted on October 7, 2026

Governance key to balancing AI augmentation, risk for deskilling

An aircraft’s autopilot can guide every aspect of a flight, from takeoff to landing. But it is expected, and reassuring to know, that a pilot has the skills to intervene and assume manual control at any time, especially during an emergency. There is a similar expectation for healthcare professionals, who increasingly encounter AI’s expansion in practice to aid clinical diagnoses, documentation and decision-making. The concern? That overreliance on AI could eventually erode clinical skills and competencies, a phenomenon dubbed “deskilling.” “Research is showing that there is a fine line between

Posted on October 6, 2026

Potent P2Y12s show no benefit in patients with AF, ACS

MUNICH — Potent P2Y12 inhibition plus direct oral anticoagulation did not cut ischemic risk and raised bleeding risk vs. clopidogrel and direct oral anticoagulants in patients with atrial fibrillation and acute coronary syndrome, data show. The results of the EPIDAURUS trial that evaluated the optimal antithrombotic regimen in patients with AF and ACS undergoing percutaneous coronary intervention were presented at the European Society of Cardiology Congress and simultaneously published in Nature Medicine. The trial was prematurely terminated after enrollment due to safety concerns from the

Posted on October 6, 2026

Q&A: How women physicians can find joy in personal finance

Brittne Halford, MD, MPH, paid off $138,000 in medical school debt in 2 years and 9 months without feeling (terribly) deprived of the good things in life. “I am from a family that’s rich in culture and community and support, but not as far as passing down wealth. My parents could not afford to send me to college, but I was able to acquire enough scholarships to pay for undergrad and matriculate to medical school,” Halford, an internal medicine physician and financial coach, told Healio. “Like many individuals, I had a lot of graduate school debt, and I saw how it was

Posted on October 6, 2026

ASCVD risk from high Lp(a) persists into old age

MUNICH — The risk for atherosclerotic CVD in adults with high lipoprotein(a) levels is similar between older and younger adults. However, the absolute risk is highest for older individuals aged 70 to 100 years, according to study findings. The results of the Copenhagen General Population Study were presented at the European Society of Cardiology Congress and simultaneously published in Circulation. The connection between high Lp(a) and ASCVD has been proven, but there was not much research available on high Lp(a) levels as a risk in individuals older than 70 years — and specifically those aged

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