Influence of mitral regurgitation repair on survival in the Surgical Treatment for Ischemic Heart Failure (STICH) Trial
Jun 18, 2012
Overview:This study assessed the survival impact of functional mitral regurgitation (MR) in patients with ischemic heart disease and low ejection fraction (EF<35%). The authors also assessed the impact of adding mitral valve repair (MVrep) at the time of CABG on... more
Dilatation of the Remaining Aorta After Aortic Valve or Aortic Root Replacement in Patients With Bicuspid Aortic Valve: A 5-Year Follow-Up
Aug 16, 2013
Overview:Background Bicuspid aortic valve (BAV) is the underlying pathology in as many as 1/3 of patients who undergo aortic valve replacement (AVR). It is now widely accepted that an inherent aortopathy exists independent of functional valvular pathology in many patients... more
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomization study
Jun 18, 2012
Overview:The present study sought to assess whether there is a causal relationship between raising HDL and the risk for myocardial infarction (MI). Using a mendelian randomization, the authors found that in patients with genetically higher HDL the risk of MI... more
Testosterone and the Heart
Mar 09, 2021
Overview:Testosterone deficiency (TD) is a well-established and significant medical condition.1,2 It has been defined as a clinical and biochemical syndrome, associated with older age and comorbidities.3 It is characterised by a deficiency in serum androgen levels, with or without reduced genomic sensitivity... more
HRT after MI: adverse events
May 02, 2012
Overview:Discontinuation of hormone replacement therapy after myocardial infarction and short term risk of adverse cardiovascular events: nationwide cohort study Background Guidelines recommend discontinuation of hormone-replacement therapy (HRT) in women diagnosed with coronary artery disease. Discontinuation of HRT can be troublesome... more
Typical angina without significant coronary stenosis: comparison of clinical profile, circadian presentation, and long-term follow-up between patients with and patients without vasospastic angina
Aug 07, 2013
Overview:Background The spectrum of patients with chest and no significant coronary stenosis is broad, with a wide range of lumen obstruction (from smooth completely normal coronary arteries to those with lesions <50%) and also including abnormal vasomotion (vasospastic angina-VA, microvascular... more
Noise Pollution and Arterial Hypertension
Aug 15, 2018
Overview:The health burden of environmental noise has recently been quantified in a report of the World Health Organization (WHO) in terms of disability adjusted life years (DALYs; i.e., the number of years lost because of disability or death – a... more
Retraction of the Jikei Heart Study
Oct 21, 2013
Overview:In 2007, the Lancet published the results of the Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded endpoint morbidity-mortality study (1). According to the authors, the addition of the angiotensin... more
A LONG-AWAITED LDL LOWERING STUDY USING COMBINATION THERAPY IS PRESENTED BY RESEARCHERS
Dec 03, 2014
Overview:STUDY DESIGN A total of 18,144 patients were randomized in 1:1 blinded fashion either to ezetimibe / simvastatin (n=9,067) or to simvastatin alone (n=9,077). The inclusion criteria were (a) hospitalization for ST-elevation myocardial infarction (MI), non ST-elevation myocardial infarction or... more
Long term benefit of early pre-reperfusion metoprolol administration in patients with acute myocardial infarction: results from the METOCARD-CNIC trial.
Aug 11, 2014
Overview:Background and knowledge gap β-blockers reduce mortality when administered after an AMI, and are a class IA indication in this context. Experimental models have shown that intravenous administration of metoprolol before (but not after) reperfusion of STEMI reduces infarct size1,2.... more