Risk of arrhythmias in 52 755 long-distance cross-country skiers: a cohort study

Jan 02, 2014

Overview:Background and objectives: It has been hypothesised that athlete’s heart, secondary to long term endurance sport practice, may increase the incidence of arrhythmias, particularly atrial fibrillation (AF), atrial flutter, sinus node dysfunction, and eventually right ventricular tachycardia. Several mechanisms have... more

Changes in HDL cholesterol and cardiovascular outcomes after lipid modification therapy

Jun 18, 2012

Overview:In the present study the authors aimed to replicate the earlier observation from the Framingham Offspring Study that changes in HDL-C associated with lipid modification therapy are associated with a lower risk of cardiovascular events independent of changes in LDL-C... more

Long term benefit of early pre-reperfusion metoprolol administration in patients with acute myocardial infarction: results from the METOCARD-CNIC trial.

Aug 11, 2014

Overview:Background and knowledge gap β-blockers reduce mortality when administered after an AMI, and are a class IA indication in this context. Experimental models have shown that intravenous administration of metoprolol before (but not after) reperfusion of STEMI reduces infarct size1,2.... more

Lowering LDL-C with statins in patients at low risk of vascular disease: a meta-analysis

Jun 18, 2012

Overview:  Background Both clinical trials and very large meta-analyses have shown that statins reduce LDL- cholesterol (LDL-C) and prevent cardiovascular disease (CVD) events. This meta-analysis explored the lipid-lowering effects of statin therapy in patients at very low risk of CVD.... more

Losartan versus candesartan in HF

Jun 18, 2012

Overview:Association of treatment with losartan vs candesartan and mortality among patients with heart failure In the present study the authors asked whether losartan use is associated with increased all-cause mortality in heart failure (HF) patients compared with candesartan. Among patients... more

Percutaneous Coronary Intervention Versus Optimal Medical Therapy for Prevention of Spontaneous Myocardial Infarction in Subjects With Stable Ischemic Heart Disease

Jul 09, 2013

Overview:Background  CAD is the leading cause of death worldwide, contributing to over 7.2 million deaths  annually. Early revascularization has been well validated to show a reduction in cardiovascular events in the management of ST segment elevation MI1-3. In addition, revascularisation... more

Eplerenone and Atrial Fibrillation in Mild Systolic Heart Failure: Results From the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) Study

May 17, 2012

Overview:Background Atrial fibrosis has been recognized as a pathophysiologic substrate for atrial fibrillation or flutter (AFF) occurrence. Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) have been shown to reduce the incidence of atrial fibrillation in patients with... more

A randomized, controlled trial of simvastatin versus rosuvastatin in patients with acute myocardial infarction: the Secondary Prevention of Acute Coronary Events–Reduction of Cholesterol to Key European Targets Trial.

Aug 17, 2015

Overview:The debate over the cholesterol hypothesis and statins has raged for decades. The early period following the onset of acute coronary syndrome represents a critical stage of coronary heart disease, with a high risk of recurrent events and deaths. The... more

Association between coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus.

Aug 26, 2013

Overview:Background Patients with diabetes mellitus are considered a high risk group for of adverse cardiac events even in the absence of overt myocardial ischemia or scar compared with patients without diabetes mellitus. Impaired coronary vascular function is an early manifestation... more

Risk-benefit profile of warfarin versus aspirin in patients with heart failure and sinus rhythm: a meta-analysis.

Dec 12, 2013

Overview:Background and objectives: HF is a growing public health problem worldwide, and it is associated with an increased risk of left ventricular thrombus formation and cerebral embolism due to endothelial dysfunction, reduced blood flow and underlying state of hypercoagulability2-5. In... more