Women with Stable Angina Pectoris and No Obstructive Coronary Artery Disease: Closer to a Diagnosis

Nov 15, 2018

Overview:  Women have for many years been regarded as being at relatively low risk for the development of ischaemic heart disease (IHD).1,2 Recently this pattern has changed and cardiovascular disease (CVD) is now the leading cause of death for women in... more

Efficacy of β blockers in patients with heart failure plus atrial fibrillation: an individual-patient data meta-analysis

Oct 12, 2014

Overview:  Background and knowledge gap According to current guidelines, a rhythm-control strategy (including pharmacological or electrical cardioversion) in patients with chronic HF, has not been demonstrated to be superior to a rate-control strategy in reducing mortality or morbidity. Preference of... more

Key Recent Advances In Atherosclerosis Treatment With Modern Lipid-Lowering Drugs: The New Frontier With PCSK9 Inhibitors

Jan 04, 2019

Overview:Hypercholesterolemia has been known for several years to be a major risk factor in the development of atherosclerosis and consecutively cardiovascular disease. This epidemiological concept has been widely confirmed using different strategies that have reduced low-density lipoprotein (LDL) levels and... more

Antiplatelet Therapy In Acute Coronary Syndrome

Oct 10, 2018

Overview:  Acute coronary syndrome (ACS) is a term used to encompass unstable angina (UA) and myocardial infarction (MI) with or without electrocardiographic (ECG) evidence of ST-segment elevation. Antiplatelet therapy has formed the backbone of ACS management for decades and the... more

Sodium–Glucose Cotransporter 2 Inhibitors In Heart Failure

Nov 01, 2020

Overview:Potential Mechanisms Of Action, Adverse Effects And Future Developments Type 2 diabetes (T2D) remains a major cardiovascular (CV) risk factor1–5 and it confers an approximately two- to threefold fold excess risk for coronary heart disease, including MI, stroke and heart... more

Resistant Hypertension: A Real Entity Requiring Special Treatment?

Aug 01, 2016

Overview:The concept of resistant hypertension (RH) has received great attention in the past years, mainly as a possible target population for innovative therapeutic strategies. An increasing number of original articles and commentaries have focused on the clinical significance, prognosis and... more

Losartan versus candesartan in HF

Jun 18, 2012

Overview:Association of treatment with losartan vs candesartan and mortality among patients with heart failure In the present study the authors asked whether losartan use is associated with increased all-cause mortality in heart failure (HF) patients compared with candesartan. Among patients... more

Left Ventricular Remodelling: A Problem In Search Of Solutions

Mar 01, 2018

Overview:  The term cardiac remodelling (REM) is used to define changes that produce geometrical rearrangement of the normal structures of the heart, together with complex biological and molecular alterations. REM affects the heart at the level of the cardiomyocyte, the... more

Coronary Artery Spasm And Perivascular Adipose Tissue Inflammation: Insights From Translational Imaging Research

Aug 24, 2020

Overview:Coronary Artery Spasm and Adventitial Inflammation Coronary artery spasm plays an important role in the pathogenesis of a wide range of ischaemic heart disease, not only in variant angina, but also in other forms of angina pectoris and myocardial infarction.1,2 Recent... more

Cardiovascular Management of Adults with Marfan Syndrome

May 09, 2018

Overview:  Marfan syndrome (MFS) is a disease in which connective tissue becomes weak secondary to fibrillin-1 mutations, resulting in aortic dilatation, aneurysm formation, aortic dissection, aortic regurgitation and mitral valve prolapse (MVP; see Table 1). Epidemiology MFS is an autosomal dominant... more