Inflammation Revisited: Atherosclerosis in the Post-CANTOS Era

Oct 04, 2017

Overview:The notion that atherosclerosis carries features of an inflammatory disease has existed for quite some time. As early as 1856, Rudolf Virchow in his Textbook on Pathology mentioned the term “coronaritis”. Almost 150 years later, following the elucidation of major... more

Typical angina without significant coronary stenosis: comparison of clinical profile, circadian presentation, and long-term follow-up between patients with and patients without vasospastic angina

Aug 07, 2013

Overview:Background The spectrum of patients with chest and no significant coronary stenosis is broad, with a wide range of lumen obstruction (from smooth completely normal coronary arteries to those with lesions <50%) and also including abnormal vasomotion (vasospastic angina-VA, microvascular... more

Resistant Hypertension: A Real Entity Requiring Special Treatment?

Resistant Hypertension: A Real Entity Requiring Special Treatment?

Aug 01, 2016

Overview:The concept of resistant hypertension (RH) has received great attention in the past years, mainly as a possible target population for innovative therapeutic strategies. An increasing number of original articles and commentaries have focused on the clinical significance, prognosis and... more

Ranolazine reduces patient-reported angina severity and frequency and improves quality of life in selected patients with chronic angina

Feb 20, 2014

Overview:Background and objectives: Coronary heart disease (CHD) is the most common cause of death (and premature death) in the United Kingdom (UK) with 94,000 deaths from CHD in the UK each year (1 in 5 men and 1 in 7... more

High on-thienopyridine platelet reactivity in elderly coronary patients: the SENIOR-PLATELET study

Jun 18, 2012

Overview:The authors of this study investigated whether there is a difference between younger and older patients in the ability of thienopyridine antiplatelet drugs to inhibit platelet responsiveness. They found that, in a population of patients chronically treated with aspirin plus... more

Psychotropic medications and the risk of sudden cardiac death during an acute coronary event.

May 02, 2012

Overview:Background Mental disorders have been associated with increased risk of cardiovascular (CV) mortality, and specifically with occurrence of sudden cardiac death (SCD). There is also growing evidence that psychotropic drugs could increase the risk of SCD. Knowledge Gap At present... more

Left Ventricular Remodelling: A Problem In Search Of Solutions

Left Ventricular Remodelling: A Problem In Search Of Solutions

Mar 01, 2018

Overview:  The term cardiac remodelling (REM) is used to define changes that produce geometrical rearrangement of the normal structures of the heart, together with complex biological and molecular alterations. REM affects the heart at the level of the cardiomyocyte, the... more

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomization study

Jun 18, 2012

Overview:The present study sought to assess whether there is a causal relationship between raising HDL and the risk for myocardial infarction (MI). Using a mendelian randomization, the authors found that in patients with genetically higher HDL the risk of MI... more

Efficacy of β blockers in patients with heart failure plus atrial fibrillation: an individual-patient data meta-analysis

Oct 12, 2014

Overview:  Background and knowledge gap According to current guidelines, a rhythm-control strategy (including pharmacological or electrical cardioversion) in patients with chronic HF, has not been demonstrated to be superior to a rate-control strategy in reducing mortality or morbidity. Preference of... more

Risk of arrhythmias in 52 755 long-distance cross-country skiers: a cohort study

Jan 02, 2014

Overview:Background and objectives: It has been hypothesised that athlete’s heart, secondary to long term endurance sport practice, may increase the incidence of arrhythmias, particularly atrial fibrillation (AF), atrial flutter, sinus node dysfunction, and eventually right ventricular tachycardia. Several mechanisms have... more