Out-of-hospital administration of IV glucose-insulin-potassium in patients with suspected ACS: the IMMEDIATE trial

Jun 18, 2012

Overview:The authors investigated whether the immediate intravenous (IV) administration of glucose, insulin and potassium (GIK) in the setting of emergency medical services would reduce ischemia-related arrhythmias and myocardial injury in suspected acute coronary syndromes. Compared with placebo, GIK administration was... more

Using DOACs In Patients With AF: Assessment, Monitoring And Treatment Reversal

Using DOACs In Patients With AF: Assessment, Monitoring And Treatment Reversal

Apr 05, 2018

Overview:Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice in Western countries. The prevalence of AF depends on the population studied1 and especially on age.2–9 It is affected by increasing longevity and is modulated by the prevalence of cardiovascular... more

Inflammation Revisited: Atherosclerosis in the Post-CANTOS Era

Oct 04, 2017

Overview:The notion that atherosclerosis carries features of an inflammatory disease has existed for quite some time. As early as 1856, Rudolf Virchow in his Textbook on Pathology mentioned the term “coronaritis”. Almost 150 years later, following the elucidation of major... more

Direct Oral Anticoagulants: A Quick Guide

Dec 06, 2018

Overview:  For more than 50 years, oral vitamin K antagonists (VKAs) were the choice of anticoagulant for the long-term treatment and prevention of arterial and venous thromboembolic events (VTE). VKA treatment is safe and effective, if a high time in... more

A Pilot Project of Familial Screening in Patients with Bicuspid Aortic Valve Disease

Jul 15, 2013

Overview:Background BAV is a risk factor for aortic valve disease in adults. It may be the most common cardiovascular malformation, with an estimated incidence of 0.6% to 1.36%. Previous studies attempted to investigate the hypothesis that clinically asymptomatic BAV may... more

Women with Stable Angina Pectoris and No Obstructive Coronary Artery Disease: Closer to a Diagnosis

Nov 15, 2018

Overview:  Women have for many years been regarded as being at relatively low risk for the development of ischaemic heart disease (IHD).1,2 Recently this pattern has changed and cardiovascular disease (CVD) is now the leading cause of death for women in... more

Cardiovascular Management of Adults with Marfan Syndrome

May 09, 2018

Overview:  Marfan syndrome (MFS) is a disease in which connective tissue becomes weak secondary to fibrillin-1 mutations, resulting in aortic dilatation, aneurysm formation, aortic dissection, aortic regurgitation and mitral valve prolapse (MVP; see Table 1). Epidemiology MFS is an autosomal dominant... more

Influence of mitral regurgitation repair on survival in the Surgical Treatment for Ischemic Heart Failure (STICH) Trial

Jun 18, 2012

Overview:This study assessed the survival impact of functional mitral regurgitation (MR) in patients with ischemic heart disease and low ejection fraction (EF<35%). The authors also assessed the impact of adding mitral valve repair (MVrep) at the time of CABG on... more

Qsymia Offers ‘Really Effective’ Weight Loss

Apr 28, 2017

Overview:By Professor Juan Tamargo, Madrid, Spain Qsymia is a formulation of two off-patent drugs already on the market: immediate-release phentermine and controlled-release topiramate. Phentermine is an amphetamine-like compound, currently licensed as a short-term weight loss agent due to its central... more

First in Class ARNI, Valsartan/Sacubitril as a New Treatment of Chronic HFrEF

May 24, 2018

Overview:Sang Hong Baek MD, PhD, FACC, ESC Professor of Medicine (Cardiology), Seoul St. Mary’s Hospital, The Catholic University of Korea   Background The first approved ARNI (angiotensin receptor-nephrilysin inhibitor), valsartan/sacubitril, is a combination drug for use in chronic symptomatic heart... more