Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation

Sep 10, 2013

Overview:Background Atrial fibrillation (AF) as an age-related disease represents an increasing challenge to Western societies due to its increasing prevalence, and the burden of stroke and thromboembolism associated with this common arrhythmia. Patients with non-valvular AF (NVAF) are exposed to... more

Effectiveness and Safety of Digoxin Among Contemporary Adults With Incident Systolic Heart Failure

Sep 29, 2013

Overview:Background In the current European Society of Cardiology guidelines on heart failure (HF)1, digoxin for HF falls into the group of less-certain benefits where it is classified as class IIb, level B: digoxin could be considered to reduce risk of... more

Wine Consumption and Cardiovascular Health: An Expert Opinion

Feb 13, 2018

Overview:Adrian Baranchuk, MD, FACC, FRCPC, FCCS, Sohaib Haseeb, BSc and Bryce Alexander, BSc*   Introduction Most people enjoy wine as a social drink, taking pleasure in its flavours during recreational and personal occasions.1 It is a fermented beverage enjoyed for... more

Anticoagulation in CVD: Clinical Implications of the COMPASS Study

Jun 17, 2020

Overview:  Anticoagulation In Patients With Ischaemic Heart Disease And Peripheral Arterial Disease: Clinical Implications Of COMPASS Study Atherosclerotic cardiovascular disease (CVD) comprises a large number of related pathologies, including ischaemic heart disease and peripheral arterial disease (PAD).1 This group of... more

The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials

Jul 03, 2015

Overview:Introduction Statins inhibit cholesterol biosynthesis and decrease serum levels of low-density lipoprotein cholesterol (LDL-C) by inhibition of 3-hydroxy-3- methyl-glutaryl-coenzyme A reductase. Additional effects are widely recognized, including anti-inflammatory and anti-oxidant properties, improvement of endothelial function and angiogenesis1,2. Statins have primary... more

Direct Oral Anticoagulants: A Quick Guide

Dec 06, 2018

Overview:  For more than 50 years, oral vitamin K antagonists (VKAs) were the choice of anticoagulant for the long-term treatment and prevention of arterial and venous thromboembolic events (VTE). VKA treatment is safe and effective, if a high time in... more

Out-of-hospital administration of IV glucose-insulin-potassium in patients with suspected ACS: the IMMEDIATE trial

Jun 18, 2012

Overview:The authors investigated whether the immediate intravenous (IV) administration of glucose, insulin and potassium (GIK) in the setting of emergency medical services would reduce ischemia-related arrhythmias and myocardial injury in suspected acute coronary syndromes. Compared with placebo, GIK administration was... more

NOACs at the crossroad of arterial and venous thrombosis

Apr 22, 2019

Overview:  By Professor G.A. Dan , MD, PhD, FESC, FAHA, FACC, FEHRA* and Caterina Delcea, MD, PhD The classical theory stated that pathophysiology of thrombosis was fundamentally different in venous and arterial sites: venous or red clots were considered to... more

A Pilot Project of Familial Screening in Patients with Bicuspid Aortic Valve Disease

Jul 15, 2013

Overview:Background BAV is a risk factor for aortic valve disease in adults. It may be the most common cardiovascular malformation, with an estimated incidence of 0.6% to 1.36%. Previous studies attempted to investigate the hypothesis that clinically asymptomatic BAV may... more

Using DOACs In Patients With AF: Assessment, Monitoring And Treatment Reversal

Apr 05, 2018

Overview:Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice in Western countries. The prevalence of AF depends on the population studied1 and especially on age.2–9 It is affected by increasing longevity and is modulated by the prevalence of cardiovascular... more