Effectiveness and Safety of Digoxin Among Contemporary Adults With Incident Systolic Heart Failure

Sep 29, 2013

Overview:Background In the current European Society of Cardiology guidelines on heart failure (HF)1, digoxin for HF falls into the group of less-certain benefits where it is classified as class IIb, level B: digoxin could be considered to reduce risk of... more

Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: Findings From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial

Mar 21, 2016

Overview:Valvular heart disease (VHD) is associated with a higher incidence of thromboembolic events, regardless of the underlying cardiac rhythm [1]. Atrial fibrillation (AF) is associated with a higher incidence of thromboembolic events in patients with rheumatic mitral stenosis or in... more

Relative efficacy of antianginal drugs used as add-on therapy in patients with stable angina: A systematic review and meta-analysis.

Jan 12, 2015

Overview:Background and knowledge gap Stable angina is a form of coronary artery disease. Its potential to progress requires the most appropriate treatment in order to reduce the incapacitating effect of an acute angina attack and to avoid long-term cardiovascular events.... more

Myocardial infarction with non-obstructive coronary arteries (MINOCA)

Jul 25, 2017

Overview:By Professor Stefan Agewall A sizeable proportion of MIs, ranging between 1% and 14%, occur in the absence of obstructive coronary artery disease. The diagnostic criteria of MINOCA fulfill the universal criteria of myocardial infarction, but without coronary artery stenosis... more

Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation

Sep 10, 2013

Overview:Background Atrial fibrillation (AF) as an age-related disease represents an increasing challenge to Western societies due to its increasing prevalence, and the burden of stroke and thromboembolism associated with this common arrhythmia. Patients with non-valvular AF (NVAF) are exposed to... more

The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials

Jul 03, 2015

Overview:Introduction Statins inhibit cholesterol biosynthesis and decrease serum levels of low-density lipoprotein cholesterol (LDL-C) by inhibition of 3-hydroxy-3- methyl-glutaryl-coenzyme A reductase. Additional effects are widely recognized, including anti-inflammatory and anti-oxidant properties, improvement of endothelial function and angiogenesis1,2. Statins have primary... more

A Pilot Project of Familial Screening in Patients with Bicuspid Aortic Valve Disease

Jul 15, 2013

Overview:Background BAV is a risk factor for aortic valve disease in adults. It may be the most common cardiovascular malformation, with an estimated incidence of 0.6% to 1.36%. Previous studies attempted to investigate the hypothesis that clinically asymptomatic BAV may... more

Psychotropic medications and the risk of sudden cardiac death during an acute coronary event.

May 02, 2012

Overview:Background Mental disorders have been associated with increased risk of cardiovascular (CV) mortality, and specifically with occurrence of sudden cardiac death (SCD). There is also growing evidence that psychotropic drugs could increase the risk of SCD. Knowledge Gap At present... more

Retraction of the Jikei Heart Study

Oct 21, 2013

Overview:In 2007, the Lancet published the results of the Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded endpoint morbidity-mortality study (1). According to the authors, the addition of the angiotensin... more

Updated Clinical Classification of Pulmonary Hypertension

Mar 31, 2014

Overview:Methods The World Symposium on Pulmonary Hypertension (WSPH) convenes every 5 years to discuss updates in the field. The symposium is designed to create guidelines to improve clinical practice and to standardize both pathologic and clinical definitions. A consensus on... more