Myocardial infarction with non-obstructive coronary arteries (MINOCA)

Jul 25, 2017

Overview:By Professor Stefan Agewall A sizeable proportion of MIs, ranging between 1% and 14%, occur in the absence of obstructive coronary artery disease. The diagnostic criteria of MINOCA fulfill the universal criteria of myocardial infarction, but without coronary artery stenosis... more

Effectiveness and Safety of Digoxin Among Contemporary Adults With Incident Systolic Heart Failure

Sep 29, 2013

Overview:Background In the current European Society of Cardiology guidelines on heart failure (HF)1, digoxin for HF falls into the group of less-certain benefits where it is classified as class IIb, level B: digoxin could be considered to reduce risk of... more

Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease

Findings From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial

Mar 21, 2016

Overview:Valvular heart disease (VHD) is associated with a higher incidence of thromboembolic events, regardless of the underlying cardiac rhythm [1]. Atrial fibrillation (AF) is associated with a higher incidence of thromboembolic events in patients with rheumatic mitral stenosis or in... more

Wine Consumption and Cardiovascular Health: An Expert Opinion

Feb 13, 2018

Overview:Adrian Baranchuk, MD, FACC, FRCPC, FCCS, Sohaib Haseeb, BSc and Bryce Alexander, BSc*   Introduction Most people enjoy wine as a social drink, taking pleasure in its flavours during recreational and personal occasions.1 It is a fermented beverage enjoyed for... more

Relative efficacy of antianginal drugs used as add-on therapy in patients with stable angina: A systematic review and meta-analysis.

Jan 12, 2015

Overview:Background and knowledge gap Stable angina is a form of coronary artery disease. Its potential to progress requires the most appropriate treatment in order to reduce the incapacitating effect of an acute angina attack and to avoid long-term cardiovascular events.... more

Using DOACs In Patients With AF: Assessment, Monitoring And Treatment Reversal

Using DOACs In Patients With AF: Assessment, Monitoring And Treatment Reversal

Apr 05, 2018

Overview:Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice in Western countries. The prevalence of AF depends on the population studied1 and especially on age.2–9 It is affected by increasing longevity and is modulated by the prevalence of cardiovascular... more

Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation

Sep 10, 2013

Overview:Background Atrial fibrillation (AF) as an age-related disease represents an increasing challenge to Western societies due to its increasing prevalence, and the burden of stroke and thromboembolism associated with this common arrhythmia. Patients with non-valvular AF (NVAF) are exposed to... more

Cardiovascular Risk Management Targeting Inflammation In Addition To Lipid-Lowering Therapy

Dec 13, 2017

Overview:Myocardial infarction is often caused by the rupture of unstable plaque in atherosclerosis with mild-to-moderate stenosis. Research has revealed that local tissue inflammation is closely involved in the rupture of atherosclerotic plaque.1 Stabilization of atherosclerotic plaque by strictly managing the... more

Cardiovascular Management of Adults with Marfan Syndrome

May 09, 2018

Overview:  Marfan syndrome (MFS) is a disease in which connective tissue becomes weak secondary to fibrillin-1 mutations, resulting in aortic dilatation, aneurysm formation, aortic dissection, aortic regurgitation and mitral valve prolapse (MVP; see Table 1). Epidemiology MFS is an autosomal dominant... more

Out-of-hospital administration of IV glucose-insulin-potassium in patients with suspected ACS: the IMMEDIATE trial

Jun 18, 2012

Overview:The authors investigated whether the immediate intravenous (IV) administration of glucose, insulin and potassium (GIK) in the setting of emergency medical services would reduce ischemia-related arrhythmias and myocardial injury in suspected acute coronary syndromes. Compared with placebo, GIK administration was... more