Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Jul 09, 2019

Overview : Trial Reference Manson JE, Cook NR, Lee IM, Christen W, VITAL Research Group. Vitamin D supplements and prevention of cancer and cardiovascular disease (VITAL). N Engl J Med. 2019 Jan 3;380(1):33-44. Abstract | Full Text   Expert Comment Ricardo Lopez Santi, ISCP Governor for Argentina... more

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia: The REDUCE-IT trial

Apr 01, 2019

Overview : Trial Reference Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB et al. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia. N Engl J Med. 2019;380:11-22. Abstract | Full Text Expert Comment Maria Eliane Campos Magalhães and Andréa Araujo Brandão Background A long-standing association... more

Intravenous Iron in Patients Undergoing Maintenance Hemodialysis: the PIVOTAL trial

Feb 14, 2019

Overview : Trial References Macdougall IC, White C, Anker SD, Bhandari S, Farrington K, Kalra PA, McMurray JJV, Murray H, Tomson CRV, Wheeler DC, Winearls CG, and Ford I, for the PIVOTAL Investigators and Committees. Intravenous Iron in Patients Undergoing Maintenance Hemodialysis.... more

Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness (MARINER)

Sep 13, 2018

Overview : Trial References Spyropoulos AC, Ageno W, Albers GW, et al.; MARINER Investigators. Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness. N Engl J Med. 2018 Aug 26. doi: 10.1056/NEJMoa1805090. Abstract | Full Text Expert Comment Pablo del Castillo Vazquez,  Antoni Martínez-Rubio: Department of Cardiology, University Hospital of... more

Cardiovascular and Metabolic Effects of Lorcaserin in Overweight and Obese Patients (CAMELLIA–TIMI 61)

Sep 13, 2018

Overview : Trial References Cardiovascular and Metabolic Effects of Lorcaserin in Overweight and Obese Patients - Thrombolysis in Myocardial Infarction 61 (CAMELLIA–TIMI 61) Expert Comment Amelia Carro. Hospital Universitario Vall d’Hebrón. Universidad Autónoma de Barcelona, Barcelona, Spain. Background Obesity is a major... more

Use of Aspirin to Reduce Risk of Initial Vascular Events in Patients at Moderate Risk of Cardiovascular Disease (ARRIVE Trial)

Aug 27, 2018

Overview : Use of Aspirin to Reduce Risk of Initial Vascular Events in Patients at Moderate Risk of Cardiovascular Disease (ARRIVE): A Randomised, Double-blind, Placebo-controlled Trial Trial Reference Gaziano JM, Brotons C, Coppolecchia R, et al. Use of Aspirin to Reduce Risk... more

A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest

Aug 27, 2018

Overview : Trial Reference Perkins GD, Ji C, Deakin CD, et al.; PARAMEDIC2 Collaborators. A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest. N Engl J Med. 2018 Jul 18. doi: 10.1056/NEJMoa1806842. [Epub ahead of print] Abstract | Full Text Expert Comment Pablo Avanzas, Consultant... more

Effect of Loading Dose of Atorvastatin Prior to Planned PCI: The SECURE-PCI Randomized Clinical Trial

Apr 18, 2018

Overview : Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome. The SECURE-PCI Randomized Clinical Trial   Trial References Patti G, Cannon CP, Murphy SA, et al. Clinical benefit of statin... more

PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock

Jan 12, 2018

Overview : Trial Reference Thiele H, Akin I, Sandri M et al. PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock. N Engl J Med. 2017 Dec 21;377(25):2419-2432. Abstract | Full Text Expert Comment Pablo Avanzas. Professor of Medicine. Universidad de Oviedo.... more

THE OPERA TRIAL: Fish Oil and Postoperative Atrial Fibrillation: The Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation Randomized Trial”

Jul 17, 2014

Overview : The subjects of this double-blind randomized trial were 1,516 patients (mean age 64 years) scheduled to undergo cardiac surgery (valve surgery in approximately 50%). The patients randomly were assigned to receive a preoperative loading dose of 10 g of n-3... more