Cardiovascular Management of Adults with Marfan Syndrome

May 09, 2018

Overview :   Marfan syndrome (MFS) is a disease in which connective tissue becomes weak secondary to fibrillin-1 mutations, resulting in aortic dilatation, aneurysm formation, aortic dissection, aortic regurgitation and mitral valve prolapse (MVP; see Table 1). Epidemiology MFS is an autosomal dominant... more

Using DOACs In Patients With AF: Assessment, Monitoring And Treatment Reversal

Apr 05, 2018

Overview : Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice in Western countries. The prevalence of AF depends on the population studied1 and especially on age.2–9 It is affected by increasing longevity and is modulated by the prevalence of cardiovascular... more

Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation MI patients with expected delays due to long-distance transfers

Jun 18, 2012

Overview : This investigates the safety and efficacy of a pharmaco-invasive reperfusion strategy utilizing half-dose fibrinolysis combined with transfer for immediate PCI in STEMI patients presenting to remote rural hospitals. The authors found no significant differences in 30-day mortality, stroke, major bleeding,... more

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease

May 02, 2012

Overview : Background Endothelial nitric oxide synthase (eNOS) plays an important role in maintenance of endothelial function and vascular homeostasis. Tetrahydrobiopterin is an essential cofactor for eNOS. Elevation of endogenous BH4 levels by oral BH4 treatment has been suggested as a possible... more