Cardiovascular Risk Management Targeting Inflammation In Addition To Lipid-Lowering Therapy

Dec 13, 2017

Overview : Myocardial infarction is often caused by the rupture of unstable plaque in atherosclerosis with mild-to-moderate stenosis. Research has revealed that local tissue inflammation is closely involved in the rupture of atherosclerotic plaque.1 Stabilization of atherosclerotic plaque by strictly managing the... more

Inflammation Revisited: Atherosclerosis in the Post-CANTOS Era

Oct 04, 2017

Overview : The notion that atherosclerosis carries features of an inflammatory disease has existed for quite some time. As early as 1856, Rudolf Virchow in his Textbook on Pathology mentioned the term “coronaritis”. Almost 150 years later, following the elucidation of major... more

The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials

Jul 03, 2015

Overview : Introduction Statins inhibit cholesterol biosynthesis and decrease serum levels of low-density lipoprotein cholesterol (LDL-C) by inhibition of 3-hydroxy-3- methyl-glutaryl-coenzyme A reductase. Additional effects are widely recognized, including anti-inflammatory and anti-oxidant properties, improvement of endothelial function and angiogenesis1,2. Statins have primary... more

Efficacy of β blockers in patients with heart failure plus atrial fibrillation: an individual-patient data meta-analysis

Oct 12, 2014

Overview :   Background and knowledge gap According to current guidelines, a rhythm-control strategy (including pharmacological or electrical cardioversion) in patients with chronic HF, has not been demonstrated to be superior to a rate-control strategy in reducing mortality or morbidity. Preference of... more

Risk-benefit profile of warfarin versus aspirin in patients with heart failure and sinus rhythm: a meta-analysis.

Dec 12, 2013

Overview : Background and objectives: HF is a growing public health problem worldwide, and it is associated with an increased risk of left ventricular thrombus formation and cerebral embolism due to endothelial dysfunction, reduced blood flow and underlying state of hypercoagulability2-5. In... more

Effectiveness and Safety of Digoxin Among Contemporary Adults With Incident Systolic Heart Failure

Sep 29, 2013

Overview : Background In the current European Society of Cardiology guidelines on heart failure (HF)1, digoxin for HF falls into the group of less-certain benefits where it is classified as class IIb, level B: digoxin could be considered to reduce risk of... more

Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation MI patients with expected delays due to long-distance transfers

Jun 18, 2012

Overview : This investigates the safety and efficacy of a pharmaco-invasive reperfusion strategy utilizing half-dose fibrinolysis combined with transfer for immediate PCI in STEMI patients presenting to remote rural hospitals. The authors found no significant differences in 30-day mortality, stroke, major bleeding,... more

Influence of mitral regurgitation repair on survival in the Surgical Treatment for Ischemic Heart Failure (STICH) Trial

Jun 18, 2012

Overview : This study assessed the survival impact of functional mitral regurgitation (MR) in patients with ischemic heart disease and low ejection fraction (EF<35%). The authors also assessed the impact of adding mitral valve repair (MVrep) at the time of CABG on... more

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomization study

Jun 18, 2012

Overview : The present study sought to assess whether there is a causal relationship between raising HDL and the risk for myocardial infarction (MI). Using a mendelian randomization, the authors found that in patients with genetically higher HDL the risk of MI... more

Association of treatment with losartan vs candesartan and mortality among patients with heart failure

Jun 18, 2012

Overview : In the present study the authors asked whether losartan use is associated with increased all-cause mortality in heart failure (HF) patients compared with candesartan. Among patients with HF, the overall use of losartan compared with candesartan was not associated with... more