Anticoagulation in CVD: Clinical Implications of the COMPASS Study

Jun 17, 2020

Overview :   Anticoagulation In Patients With Ischaemic Heart Disease And Peripheral Arterial Disease: Clinical Implications Of COMPASS Study Atherosclerotic cardiovascular disease (CVD) comprises a large number of related pathologies, including ischaemic heart disease and peripheral arterial disease (PAD).1 This group of... more

Role Of Anti-Inflammatory Interventions In Coronary Artery Disease: Understanding CANTOS

Mar 02, 2020

Overview :   Coronary artery disease (CAD) is the leading cause of death in most countries. Compelling evidence from epidemiological, genetic and clinical studies as well as experiments in animal models has unquestionably established that elevated concentrations of cholesterol (mainly transported by... more

Nicorandil and Long-Acting Nitrates: Vasodilator Therapies for the Management of Chronic Stable Angina Pectoris

Jan 14, 2020

Overview :   Stable angina pectoris is the most prevalent clinical manifestation of coronary heart disease. While the overall prognosis in patients with stable angina is good, with a low yearly event rate of ~1–2 %,1 for many, adequate symptom control can... more

Management Of Severe Dyslipidaemia: Role Of PCSK9 Inhibitors

Dec 12, 2019

Overview :   Therapeutic targeting of dyslipidaemia has been one of the major successes in cardiovascular medicine over the last three decades. On the basis of unequivocal evidence from animal models through to both population and genetic studies in humans, there is... more

Viewpoint: Recent Advances In Intracoronary Imaging For Vasa Vasorum Visualisation

Feb 08, 2019

Overview :   Vasa Vasorum The coronary arterial wall generally consists of the tunica intima, tunica media and tunica adventitia. In particular, the coronary adventitia harbours the vasa vasorum (VV),which has a diameter of 50–300 μm and plays an important role as... more

Women with Stable Angina Pectoris and No Obstructive Coronary Artery Disease: Closer to a Diagnosis

Nov 15, 2018

Overview :   Women have for many years been regarded as being at relatively low risk for the development of ischaemic heart disease (IHD).1,2 Recently this pattern has changed and cardiovascular disease (CVD) is now the leading cause of death for women in... more

Cardiovascular Risk Management Targeting Inflammation In Addition To Lipid-Lowering Therapy

Dec 13, 2017

Overview : Myocardial infarction is often caused by the rupture of unstable plaque in atherosclerosis with mild-to-moderate stenosis. Research has revealed that local tissue inflammation is closely involved in the rupture of atherosclerotic plaque.1 Stabilization of atherosclerotic plaque by strictly managing the... more

Inflammation Revisited: Atherosclerosis in the Post-CANTOS Era

Oct 04, 2017

Overview : The notion that atherosclerosis carries features of an inflammatory disease has existed for quite some time. As early as 1856, Rudolf Virchow in his Textbook on Pathology mentioned the term “coronaritis”. Almost 150 years later, following the elucidation of major... more

Ranolazine reduces patient-reported angina severity and frequency and improves quality of life in selected patients with chronic angina

Feb 20, 2014

Overview : Background and objectives: Coronary heart disease (CHD) is the most common cause of death (and premature death) in the United Kingdom (UK) with 94,000 deaths from CHD in the UK each year (1 in 5 men and 1 in 7... more

Typical angina without significant coronary stenosis: comparison of clinical profile, circadian presentation, and long-term follow-up between patients with and patients without vasospastic angina

Aug 07, 2013

Overview : Background The spectrum of patients with chest and no significant coronary stenosis is broad, with a wide range of lumen obstruction (from smooth completely normal coronary arteries to those with lesions <50%) and also including abnormal vasomotion (vasospastic angina-VA, microvascular... more