Cardiovascular Management of Adults with Marfan Syndrome

May 09, 2018

Overview :   Marfan syndrome (MFS) is a disease in which connective tissue becomes weak secondary to fibrillin-1 mutations, resulting in aortic dilatation, aneurysm formation, aortic dissection, aortic regurgitation and mitral valve prolapse (MVP; see Table 1). Epidemiology MFS is an autosomal dominant... more

Using DOACs In Patients With AF: Assessment, Monitoring And Treatment Reversal

Apr 05, 2018

Overview : Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice in Western countries. The prevalence of AF depends on the population studied1 and especially on age.2–9 It is affected by increasing longevity and is modulated by the prevalence of cardiovascular... more

Left Ventricular Remodelling: A Problem In Search Of Solutions

Mar 01, 2018

Overview :   The term cardiac remodelling (REM) is used to define changes that produce geometrical rearrangement of the normal structures of the heart, together with complex biological and molecular alterations. REM affects the heart at the level of the cardiomyocyte, the... more

Risk of arrhythmias in 52 755 long-distance cross-country skiers: a cohort study

Jan 02, 2014

Overview : Background and objectives: It has been hypothesised that athlete’s heart, secondary to long term endurance sport practice, may increase the incidence of arrhythmias, particularly atrial fibrillation (AF), atrial flutter, sinus node dysfunction, and eventually right ventricular tachycardia. Several mechanisms have... more

Eplerenone and Atrial Fibrillation in Mild Systolic Heart Failure: Results From the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) Study

May 17, 2012

Overview : Background Atrial fibrosis has been recognized as a pathophysiologic substrate for atrial fibrillation or flutter (AFF) occurrence. Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) have been shown to reduce the incidence of atrial fibrillation in patients with... more

Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation

May 17, 2012

Overview : Background Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, occurring in 1–2% of the general population. The main goal of AF treatment is to avoid thromboembolic events (fivefold increased risk compared with those in sinus rhythm) by instituting... more

Psychotropic medications and the risk of sudden cardiac death during an acute coronary event.

May 02, 2012

Overview : Background Mental disorders have been associated with increased risk of cardiovascular (CV) mortality, and specifically with occurrence of sudden cardiac death (SCD). There is also growing evidence that psychotropic drugs could increase the risk of SCD. Knowledge Gap At present... more

Feasibility and safety of dabigatran versus warfarin for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: Results from a multicenter prospective registry.

May 02, 2012

Overview : Background Radiofrequency catheter ablation of atrial fibrillation (AF) is evolving as a standard therapeutic procedure for both paroxysmal and persistent forms of this arrhythmia. It is obvious for many reasons that this invasive procedure - which is performed more and... more