Direct Oral Anticoagulants: A Quick Guide

Dec 06, 2018

Overview :   For more than 50 years, oral vitamin K antagonists (VKAs) were the choice of anticoagulant for the long-term treatment and prevention of arterial and venous thromboembolic events (VTE). VKA treatment is safe and effective, if a high time in... more

Antiplatelet Therapy In Acute Coronary Syndrome

Oct 10, 2018

Overview :   Acute coronary syndrome (ACS) is a term used to encompass unstable angina (UA) and myocardial infarction (MI) with or without electrocardiographic (ECG) evidence of ST-segment elevation. Antiplatelet therapy has formed the backbone of ACS management for decades and the... more

Left Ventricular Remodelling: A Problem In Search Of Solutions

Mar 01, 2018

Overview :   The term cardiac remodelling (REM) is used to define changes that produce geometrical rearrangement of the normal structures of the heart, together with complex biological and molecular alterations. REM affects the heart at the level of the cardiomyocyte, the... more

Cardiovascular Risk Management Targeting Inflammation In Addition To Lipid-Lowering Therapy

Dec 13, 2017

Overview : Myocardial infarction is often caused by the rupture of unstable plaque in atherosclerosis with mild-to-moderate stenosis. Research has revealed that local tissue inflammation is closely involved in the rupture of atherosclerotic plaque.1 Stabilization of atherosclerotic plaque by strictly managing the... more

Inflammation Revisited: Atherosclerosis in the Post-CANTOS Era

Oct 04, 2017

Overview : The notion that atherosclerosis carries features of an inflammatory disease has existed for quite some time. As early as 1856, Rudolf Virchow in his Textbook on Pathology mentioned the term “coronaritis”. Almost 150 years later, following the elucidation of major... more

Prior antiplatelet or anticoagulant therapy and mortality in stroke

Jun 18, 2012

Overview : The authors of the present study investigated the influence of previous antiplatelet (AP) or anticoagulant (AC) therapy on subsequent stroke mortality at different time points up to one year post stroke. The authors found that prior antiplatelet or anticoagulant use... more

Out-of-hospital administration of IV glucose-insulin-potassium in patients with suspected ACS: the IMMEDIATE trial

Jun 18, 2012

Overview : The authors investigated whether the immediate intravenous (IV) administration of glucose, insulin and potassium (GIK) in the setting of emergency medical services would reduce ischemia-related arrhythmias and myocardial injury in suspected acute coronary syndromes. Compared with placebo, GIK administration was... more

Changes in HDL cholesterol and cardiovascular outcomes after lipid modification therapy

Jun 18, 2012

Overview : In the present study the authors aimed to replicate the earlier observation from the Framingham Offspring Study that changes in HDL-C associated with lipid modification therapy are associated with a lower risk of cardiovascular events independent of changes in LDL-C... more

High on-thienopyridine platelet reactivity in elderly coronary patients: the SENIOR-PLATELET study

Jun 18, 2012

Overview : The authors of this study investigated whether there is a difference between younger and older patients in the ability of thienopyridine antiplatelet drugs to inhibit platelet responsiveness. They found that, in a population of patients chronically treated with aspirin plus... more

Lowering LDL-C with statins in patients at low risk of vascular disease: a meta-analysis

Jun 18, 2012

Overview :   Background Both clinical trials and very large meta-analyses have shown that statins reduce LDL- cholesterol (LDL-C) and prevent cardiovascular disease (CVD) events. This meta-analysis explored the lipid-lowering effects of statin therapy in patients at very low risk of CVD.... more