ISCP Japan — Governor Biography

Hasegawa-Photo

Koji Hasegawa, MD

Dr Koji Hasegawa,
Director of the Division of Translational Research,
Kyoto Medical Center, National Hospital Organization
1-1 Fukakusa-mukaihata-cho

Fushimi-ku, Kyoto 612-8555, Japan

Fax: +81-75-641-9252

mail: koj@kuhp.kyoto-u.ac.jp

EDUCATION, MEDICAL LICENSURE and DOCTOR’S DEGREE

1985 M.D. Faculty of Medicine, Kyoto University

1993 Ph.D. Graduate School of Medicine Kyoto University

2000- Fellow of the American College of Cardiology (FACC)

2008- Fellow of the American Heart Association (FAHA),

Council on Basic Cardiovascular Sciences

2009-                             Leader of Cardiovascular division,

Joint Research Network, National Hospital Organization

 

RECENT MAJOR FINANCIAL SUPPORT

 

2008- 2010 Ministry of Health, Labour and Welfare

Health and Labour Sciences Research Grants, Research on Publicly Essential Drugs and Medical Devices (Japan Health Sciences Foundation)

“Novel heart failure therapy targeting differentiation of endogenous stem cells and signal transduction network of cardiomyocyte hypertrophy”

2007-2008                 Japan Society for the Promotion of Science

Grant-in-Aid for Scientific Research (B) “Translational research for signal transduction mechanisms of differentiation, regeneration, and hypertrophy of cardiomyocytes”

 

 

RECENT MAJOR PUBLICATIONS

  1. Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Hasegawa K. Distinct characteristics of circulating vascular endothelial growth factor-a and C levels in human subjects. PLoS One. 2011;6(12):e29351
  2. Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T. MicroRNA-33 encoded by an intron of Srebp2 regulated HDL in vivo Proc Natl Acad Sci U S A 2010; 107: 17321-17326
  3. Kaichi S, Hasegawa K, Takaya T, Yokoo N, Kawamura T, Morimoto T, Ono K, Baba S, Yamanaka S, Nakahata T, Heike T. Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. Cardiovasc Res 2010; 88: 314-323
  4. Horie T, Ono K, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Mori RT, Nishi E, Hasegawa K, Kita T, Kimura T. Acute Doxorubicin Cardiotoxicity Is Associated with miR-146a-induced Inhibition of the Neuregulin-ErbB Pathway. Cardiovasc Res 2010; 87: 656-664
  5. Sunagawa Y, Morimoto T, Takaya T, Kaichi S, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, Hasegawa K. Cyclin-dependent kinase-9 is a component of p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. J Biol Chem 2010 ;285:9556-9678
  6. Nishi H, Ono K, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Mori RT, Hasegawa K, Kita T, Kimura T. MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes. J Biol Chem. 2010; 285: 4920-4930.
  7. Takaya T, Kawamura T, Morimoto T, Ono K, Kita T, Shimatsu A, Hasegawa K. Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes. J Biol Chem 2008; 283:9828-9835
  8. Morimoto T, Sunagawa Y, Kawamura T, Takaya T, Wada H, Nagasawa A, Komeda M, Fujita M, Shimatsu A, Kita T, Hasegawa K. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest 2008;118:868-878
  9. Miyamoto S, Kawamura T, Morimoto T, Ono K, Wada H, Kawase Y, Matsumori A, Nishio R, Kita T, Hasegawa K. Histone acetyltranferase activity of p300 is required for the promotion of left ventricular remodeling following myocardial infarction in adult mice in vivo. Circulation 2006; 113: 679-690
  10. Kawamura T, Ono K, Morimoto T, Wada H, Hirai M, Hidaka K, Morisaki T, Heike T, Nakahata T, Kita T, Hasegawa K. Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. J Biol Chem. 2005;280:19682-19688
  11. Hirai M, Ono K, Morimoto T, Kawamura T, Wada H, Kita T, Hasegawa K. FOG-2 competes with GATA-4 for a transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes. J Biol Chem. 2004 ;279:37640-37650.
  12. Yanazume T, Hasegawa K, Morimoto T, Kawamura T, Wada H, Matsumori A, Kawase Y, Hirai M, Kita T. Cardiac p300 is involved in myocyte growth with decompensated heart failure. Mol Cell Biol 2003;23:3593-3606