The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials

Jul 03, 2015

Overview : Introduction Statins inhibit cholesterol biosynthesis and decrease serum levels of low-density lipoprotein cholesterol (LDL-C) by inhibition of 3-hydroxy-3- methyl-glutaryl-coenzyme A reductase. Additional effects are widely recognized, including anti-inflammatory and anti-oxidant properties, improvement of endothelial function and angiogenesis1,2. Statins have primary... more

Efficacy of β blockers in patients with heart failure plus atrial fibrillation: an individual-patient data meta-analysis

Oct 12, 2014

Overview :   Background and knowledge gap According to current guidelines, a rhythm-control strategy (including pharmacological or electrical cardioversion) in patients with chronic HF, has not been demonstrated to be superior to a rate-control strategy in reducing mortality or morbidity. Preference of... more

Risk-benefit profile of warfarin versus aspirin in patients with heart failure and sinus rhythm: a meta-analysis.

Dec 12, 2013

Overview : Background and objectives: HF is a growing public health problem worldwide, and it is associated with an increased risk of left ventricular thrombus formation and cerebral embolism due to endothelial dysfunction, reduced blood flow and underlying state of hypercoagulability2-5. In... more

Effectiveness and Safety of Digoxin Among Contemporary Adults With Incident Systolic Heart Failure

Sep 29, 2013

Overview : Background In the current European Society of Cardiology guidelines on heart failure (HF)1, digoxin for HF falls into the group of less-certain benefits where it is classified as class IIb, level B: digoxin could be considered to reduce risk of... more

Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation MI patients with expected delays due to long-distance transfers

Jun 18, 2012

Overview : This investigates the safety and efficacy of a pharmaco-invasive reperfusion strategy utilizing half-dose fibrinolysis combined with transfer for immediate PCI in STEMI patients presenting to remote rural hospitals. The authors found no significant differences in 30-day mortality, stroke, major bleeding,... more

Influence of mitral regurgitation repair on survival in the Surgical Treatment for Ischemic Heart Failure (STICH) Trial

Jun 18, 2012

Overview : This study assessed the survival impact of functional mitral regurgitation (MR) in patients with ischemic heart disease and low ejection fraction (EF<35%). The authors also assessed the impact of adding mitral valve repair (MVrep) at the time of CABG on... more

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomization study

Jun 18, 2012

Overview : The present study sought to assess whether there is a causal relationship between raising HDL and the risk for myocardial infarction (MI). Using a mendelian randomization, the authors found that in patients with genetically higher HDL the risk of MI... more

Association of treatment with losartan vs candesartan and mortality among patients with heart failure

Jun 18, 2012

Overview : In the present study the authors asked whether losartan use is associated with increased all-cause mortality in heart failure (HF) patients compared with candesartan. Among patients with HF, the overall use of losartan compared with candesartan was not associated with... more

Eplerenone and Atrial Fibrillation in Mild Systolic Heart Failure: Results From the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) Study

May 17, 2012

Overview : Background Atrial fibrosis has been recognized as a pathophysiologic substrate for atrial fibrillation or flutter (AFF) occurrence. Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) have been shown to reduce the incidence of atrial fibrillation in patients with... more

Discontinuation of hormone replacement therapy after myocardial infarction and short term risk of adverse cardiovascular events: nationwide cohort study.

May 02, 2012

Overview : Background Guidelines recommend discontinuation of hormone-replacement therapy (HRT) in women diagnosed with coronary artery disease. Discontinuation of HRT can be troublesome owing to the rebound of climacteric symptoms, as well as its theoretical favorable effects on endothelial function, inflammatory and... more