Discontinuation of hormone replacement therapy after myocardial infarction and short term risk of adverse cardiovascular events: nationwide cohort study.

May 02, 2012

Overview : Background Guidelines recommend discontinuation of hormone-replacement therapy (HRT) in women diagnosed with coronary artery disease. Discontinuation of HRT can be troublesome owing to the rebound of climacteric symptoms, as well as its theoretical favorable effects on endothelial function, inflammatory and... more

A randomized, 2-Period, crossover design study to assess the effects of dexlansoprazole, lansoprazole, esomeprazole, and omeprazole on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers

May 02, 2012

Overview : Background The co-administration of proton pump inhibitors (PPI) with clopidogrel reduces the risk of gastrointestinal (GI) bleeding associated with the antiplatelet effects of clopidogrel. There are conflicting data as to whether PPIs have the potential to reduce the effectiveness of... more