Prior antiplatelet or anticoagulant therapy and mortality in stroke

Jun 18, 2012

Overview : The authors of the present study investigated the influence of previous antiplatelet (AP) or anticoagulant (AC) therapy on subsequent stroke mortality at different time points up to one year post stroke. The authors found that prior antiplatelet or anticoagulant use... more

Out-of-hospital administration of IV glucose-insulin-potassium in patients with suspected ACS: the IMMEDIATE trial

Jun 18, 2012

Overview : The authors investigated whether the immediate intravenous (IV) administration of glucose, insulin and potassium (GIK) in the setting of emergency medical services would reduce ischemia-related arrhythmias and myocardial injury in suspected acute coronary syndromes. Compared with placebo, GIK administration was... more

Changes in HDL cholesterol and cardiovascular outcomes after lipid modification therapy

Jun 18, 2012

Overview : In the present study the authors aimed to replicate the earlier observation from the Framingham Offspring Study that changes in HDL-C associated with lipid modification therapy are associated with a lower risk of cardiovascular events independent of changes in LDL-C... more

High on-thienopyridine platelet reactivity in elderly coronary patients: the SENIOR-PLATELET study

Jun 18, 2012

Overview : The authors of this study investigated whether there is a difference between younger and older patients in the ability of thienopyridine antiplatelet drugs to inhibit platelet responsiveness. They found that, in a population of patients chronically treated with aspirin plus... more

Lowering LDL-C with statins in patients at low risk of vascular disease: a meta-analysis

Jun 18, 2012

Overview :   Background Both clinical trials and very large meta-analyses have shown that statins reduce LDL- cholesterol (LDL-C) and prevent cardiovascular disease (CVD) events. This meta-analysis explored the lipid-lowering effects of statin therapy in patients at very low risk of CVD.... more

Vorapaxar in the secondary prevention of atherothrombotic events

May 17, 2012

Overview : Background It is established that patients who had an atherosclerotic event such as stroke, myocardial infarction or peripheral artery disease receive secondary prevention medical treatment. This treatment which also comprises antiplatelet therapy using aspirin or thienopyridines has been shown to... more

Short- Versus Long-Term Duration of Dual-Antiplatelet Therapy After Coronary Stenting: A Randomized Multicenter Trial

May 17, 2012

Overview : Background Major advances in the treatment of coronary heart disease, both stable angina and acute coronary syndromes, have involved improvements in percutaneous coronary intervention; and a major component of this involves stent insertion, either of the bare metal or drug-eluting... more

Personalised antiplatelet therapy in stent thrombosis: observations from the Clopidogrel Resistance in Stent Thrombosis (CREST) registry

May 16, 2012

Overview : Background Previous studies have demonstrated significant heterogeneity in responses to APT, and high residual platelet reactivity is associated with the risk of ischaemic events, including ST. Knowledge Gap The clinical impact of APT is unknown in the “real world’ setting Aim... more

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease

May 02, 2012

Overview : Background Endothelial nitric oxide synthase (eNOS) plays an important role in maintenance of endothelial function and vascular homeostasis. Tetrahydrobiopterin is an essential cofactor for eNOS. Elevation of endogenous BH4 levels by oral BH4 treatment has been suggested as a possible... more

Prior antiplatelet or anticoagulant therapy and mortality in stroke

May 02, 2012

Overview : Background Today there is widespread use of antiplatelet or anticoagulant medication for the primary prevention of cardiovascular events. Bearing in mind the associated hemorrhagic side-effects of these medications, there are potentially harmful effects especially in patients experiencing a stroke. Knowledge... more

Page: