Drug

Cardiovascular

A message from the editor of this section, Professor Juan Tamargo

Professor Juan Tamargo Old and new drugs need to demonstrate to be not only efficacious but also safe. Adverse effects, just like the therapeutic effects, of drugs, are a function of dosage or drug levels at the target organs. As Paracelsus (1493-1541) says, “All things are poison, and nothing is without poison; only the dose permits something not to be poisonous”. As doctors, one of our main interests is to protect public health and to promote the judicious use of drugs. This section exists for that reason.

Drug Interaction will be the focus of the programme of the ISCP Annual Meeting 2017, Barcelona

DrugInteracting DrugPharmacodynamic InteractionsPharmakokinetic InteractionsClinical Outcomes
DigoxinACE inhibitors: CaptoprilDecrease renal clearance of digoxinModest increase in SDC. Monitor SDC in patients with renal impairment
HeparinAlcoholHeavy drinkers were at greater risk of major heparin-associated bleeding than moderate drinkers or non-drinkersDecrease renal clearance of digoxinMay increase the risk of bleeding
HeparinCiprofloxacinThese drugs are incompatible with heparin and may form a precipitate (21-23)Heparin sodium injection should not be mixed with these drugs
HeparinGentamicinThese drugs are incompatible with heparin and may form a precipitate (21-23)Heparin sodium injection should not be mixed with these drugs
HeparinGingerHerbs produce platelet dysfunction and increase bleeding tendencyPeople taking heparin should consult with a physician with knowledge of botanical medicines
DigoxinOmeprazoleIncrease digoxin absorptionIncrease SDC
HeparinOpiod analgesicsThese drugs are incompatible with heparin and may form a precipitate (21-23)Heparin sodium injection should not be mixed with these drugs
HeparinVinblastineThese drugs are incompatible with heparin and may form a precipitate (21-23)Heparin sodium injection should not be mixed with these drugs
HeparinVitamin D (20)Heparin may interfere with activation of vitamin DOsteoporosis has been reported in patients receiving high doses of heparin for several months